Saturday, February 7

Biotin and hair loss

  ›     ›   Biotin and hair loss.

Does biotin deficiency cause hair loss?

Biotin deficiency can cause hair loss. Biotin is also known as vitamin B7 or vitamin H.
Biotin homeostasis is crucial for maintaining the health of organs, in particular, heart, brain, skin and hair. Common biotin deficiency symptoms include, hair loss, dermatitis, loss of pigment, loss of skin sensation, tingling sensation, hypotonia, ataxia, mental retardation, memory loss, ketolactic acidosis and organic aciduria. Biotin is an essential coenzyme for five carboxylases. Carboxylases play essential roles in the metabolism of fatty acids, amino acids and glucose.

Biotin deficiency

It was considered that biotin deficiency is fairly rare. However recent research has established that marginal insufficiency of vitamin B7 is much more common than it was thought in the past. The intestinal flora also synthesizes this vitamin.
  • Dietary insufficiency, loss of intestinal flora and decreased uptake from the intestines are the main causes of biotin deficiency.
Popular topics:
  • Vitamin B7 is water-soluble and like all water-soluble vitamins, it is not stored in the body and requires daily dietary intake.
  • Pregnant and lactating women are prone to develop the insufficiency of the vitamin due to the increased demand and increased biotin catabolism.
  • Individuals being treated with anticonvulsants and other antiseizure medications are likely to develop the deficiency.
  • The insufficiency of vitamin B7 develops in patients under long term antibiotic therapy.
  • The consumption of lipoic acid or alcohol reduces the biotin absorption by the intestines. Alcoholism is known to cause hair loss.
  • Consuming raw egg causes deficiency of the vitamin. Raw egg white contains the protein avidin. The avidin binds to the biotin and renders it unavailable for absorption in the intestine.
  • Digestive disorders, malabsorption syndrome, chronic small-intestinal diseases, damage to the intestinal lining, irritable bowel syndrome and short bowel syndrome can render a person deficient in the vitamin.
  • Smoking accelerates biotin degradation and causes marginal insufficiency. Smoking is known to cause hair loss and baldness.
  • Patients who have undergone surgical removal of part of intestine or stomach are prone to develop vitamin B7 insufficiency.
  • Severely malnourished children develop biotin deficiency.
  • Genetic mutations can cause decreased activity of certain proteins involved in absorption in intestines and reabsorption in the kidneys leading vitamin B7 insufficiency in the body.
Janos Zempleni et al reported that decreased activity of certain proteins such as "monocarboxylate transporter 1, sodium-dependent multivitamin transporter, the biotin protein ligase holocarboxylase synthetase and the biotin peptidyl hydrolase biotinidase" can precipitate biotin deficiency. These proteins play crucial role in the intestinal absorption of biotin, its transport in plasma, its renal reabsorption and in the regulation of histone biotinylation. Biotinidase is present in pancreatic fluids and intestinal secretions plays a critical role in releasing free biotin from biocytin and biotinylated peptides prior to absorption.

Biotin deficiency and hair loss

The consequences of vitamin B7 insufficiency occur slowly and cumulatively. Biotin is essential for maintaining a healthy skin and the skin appendages like hair, nails, sebaceous glands and sweat glands. Vitamin B7 deficient cells undergo senescence earlier than the normal cells. As the consequence, the hair growth is slowed down, with increase in daily loss of telogen strands.

Mitochondria has an important function in cellular senescence and aging. Vitamin B7 insufficiency causes loss of mitochondrial complex IV, which is the the main oxygen-metabolizing enzyme converting most of cellular oxygen to water. In biotin deficiency, the levels of oxidants and the oxidative damage increase leading to DNA damage and cellular senescence. Thus all the cells in hair follicles undergo cellular damage causing their loss in the event of biotin deficiency.
Advertisements

Related topics in natural skin care:
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
Reference:
1.Trüeb RM. Association between smoking and hair loss: another opportunity for health education against smoking? Dermatology. 2003;206(3):189-91.
2.Daniells S, Hardy G. Hair loss in long-term or home parenteral nutrition: are micronutrient deficiencies to blame? Curr Opin Clin Nutr Metab Care. 2010 Nov;13(6):690-7.
3.Janos Zempleni, Yousef I Hassan, Subhashinee SK Wijeratne. Biotin and biotinidase deficiency. Expert Rev Endocrinol Metab. 2008 Nov 1; 3(6): 715–724.
4.Ablon Glynis. A Double-blind, Placebo-controlled Study Evaluating the Efficacy of an Oral Supplement in Women with Self-perceived Thinning Hair. J Clin Aesthet Dermatol. 2012 Nov; 5(11): 28–34.
5.Atamna H, Newberry J, Erlitzki R, Schultz CS, Ames BN. Biotin deficiency inhibits heme synthesis and impairs mitochondria in human lung fibroblasts. J Nutr. 2007 Jan;137(1):25-30.
Interesting topics in natural skin care:
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
Current topic in natural skin care: Biotin deficiency can cause hair loss.
Get fair glowing skin complexion. Remove acne scars and blemishes from face.

No comments: