Structure of basal cell layerStratum basale is usually one keratinocyte deep with melanocytes and Langerhans or immune cells dispersed in between. These melanocytes synthesize melanin pigment, giving color and hue to the skin and the hair. The amount of melanin produced though predetermined genetically, is affected by sun exposure levels leading to increase or decrease in production. The Merkel nerve endings (neuroectodermal origin) which have tactile or touch sensation function are also dispersed in this germinativum epidermis. As this basal stratum is in close contact with dermis, it is nurtured with oxygen and nutrients by dermis by diffusion process.
Functions of basal cell layer
The lower basal daughter keratinocyte remains in the stratum basale and undergoes growth and maturation for the next mitosis. As the stratum cornium is continuously sloughed off, the mitosis and replacement activity at basal region should continuously go on. The proliferation and differentiation of basal epidermal region is regulated by Vitamin D3 (cholecalciferol).
Any chemical, physical, physiological, radiological or pathgenic disturbance of this cell proliferation activity at basal germinativum brings about dermal ailments.
- Skin sensitive to touch.
- Different type of facial skin.
- Main functions of human skin.
- Know your skin.
- Nourishing skin with fruits and vegetables.
- Small itchy water blisters on hands and feet.
- Cosmetic laser treatments - Types of cosmetic lasers.
- What are salmon patches? - Nevus simplex birthmarks on babies.
- What is a hemangioma? - What are the causes of hemangioma?
- Hemangioma treatments - Hemangioma removal.
Harding, C. R. (2004), The stratum corneum: structure and function in health and disease. Dermatologic Therapy, 17: 6–15. doi: 10.1111/j.1396-0296.2004.04S1001.x
Author:Mikael Häggström, based on work by Wbensmith
License: CC BY-SA 3.0
Current topic: Basal layer cells of epidermal skin.