Showing posts with label what. Show all posts
Showing posts with label what. Show all posts

Wednesday, January 28

What is telogen effluvium? - Telogen effluvium definition

  ›     ›     ›   What is telogen effluvium? - Telogen effluvium definition.

What is telogen effluvium?

Telogen effluvium is excessive shedding of hair during the resting or telogen phase.
In normal circumstances, at any given time, 80% to 90% of hairs of a person are in the growth (anagen) phase. The rest are in the transitional (catagen) and the resting (telogen) phases. The length of hair depends upon the duration of follicular growth phase, which in turn is genetically defined and determined.

The length of anagen phase differs in different areas of the body and in the same area under different conditions. When the follicular growth phase reaches the defined duration, the hair follicle, passing through the transitional stage, is transformed into telogen stage with the associated cellular changes. The resting may last up to two months.

In many mammals, the hair growth phases are synchronous and the coat shedding is apparent. In humans, the follicular growth phases are asynchronous.
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Each follicle is independently switches from growth phase to resting phase and vice versa. At the end of telogen, the follicle is reactivated and goes through cellular changes. The new hair pushes out the hair in the resting stage, leading to its detachment and shedding.

Typically a person sheds 50 to 100 hairs per day. When the loss of hair is greater than hundred strands and is very apparent on the comb and pillow, we may consider the loss as telogen hair loss. There will be thinning of the hair. The typical symptom of telogen effluvium is the presence of barely perceptible hair bulb on the end of the hair.

Due to many causative factors, the initiation of and the growth of new hair is delayed, leading to increase in the percentage of telogen hair and increase in shedding and generalized thinning. There may be abrupt shift of an increased number of growing hairs into resting stage.
Related topics: Causes - Treatment
Definition of telogen effluvium
Definition: considering what is telogen effluvium, it can be defined and summarize as "increased loss of hair, abrupt shift in growth phase to resting stage and delay in onset of fresh growth."
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Reference:
1.Whiting, DA. Chronic telogen effluvium: Increased scalp hair shedding in middle-aged women. Journal of the American Academy of Dermatology 35(6): 899-906 ,1996.
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Sunday, November 30

What is herpes zoster - Definition of herpes zoster

   ›      ›   What is herpes zoster - Herpes zoster definition.

What is herpes zoster?

Herpes zoster, also known as shingles or zona, is a viral disease caused by the chickenpox virus, varicella zoster virus (VZV).
Herpes zoster virus as a primary infection causes chickenpox in children and young adults. After the episode of primary infection by VZV, causing body rash and blisters, the symptoms resolve in 6-10 days and the patient develops partial immunity. However the herpes virus is not eliminated from the body after the primary infection. The herpes virus remains latent in the nerve ganglia and nerve bodies.

Approximately, 20% of those who had chickenpox may develop shingles later on. The latency period of the herpes virus may last from years to decades. What activates this latent human herpesvirus 3 is not known. However certain triggering factors have been identified. Individuals of all age groups and genders may develop the herpes disease. However, the incidences of its recurrence are greater in older population. Infants, elderly people, transplant patients and those affected by immunosuppression due to diseases or medications are at increased risk.

?

Shingles is caused by VZV. VZV belongs to the large family of DNA herpes viruses known as Herpesviridae. Herpes simplex viruses 1 and 2, VZV, Epstein-Barr virus, cytomegalovirus, herpesvirus 6, herpesvirus 7, and Kaposi's sarcoma-associated herpesvirus belong to the family Herpesviridae. All these viral groups are DNA viruses and once infected they remain in the body and can reemerge from latency to cause disease symptoms.

What are the ?

The early symptoms of VZV herpes are fever, headache, body pain and malaise. They are followed by tingling, itching, prickling or burning sensations.
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The sensations may be only at the site of emergence of blister or on the entire dermatome. Simultaneously a small red band of rash appears, which soon develops small blisters. The blisters get filled with serum. Then the herpes blisters may get filled with blood and the resolution phase starts. The skin develops crust which subsequently falls off.

What is the treatment for herpes zoster?

Shingles resolves by itself after 7-10 days. The antiviral drugs such as acyclovir, valacyclovir, and famciclovir can reduce the intensity of the herpes episode and help in rapid healing if taken within three days of the start of symptoms. Herpes vaccine helps in reducing the intensity and recurrence of the episodes.

Definition

  • Definition by medical-dictionary.thefreedictionary.com: "an acute, unilateral, self-limited inflammatory disease of cerebral ganglia and the ganglia of posterior nerve roots and peripheral nerves in a segmented distribution, believed to represent activation of latent human herpesvirus 3 in those who have been rendered partially immune after a previous attack of chickenpox."
  • Definition by webmd.com: "Shingles is a painful skin rash. It is caused by the varicella zoster virus. Shingles usually appears in a band, a strip, or a small area on one side of the face or body."
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    Reference:
    1.Zostavax (Herpes Zoster Vaccine) Questions and Answers (FDA)
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    Friday, October 31

    Vellus hair definition - What is vellus hair?

       ›      ›   What is vellus hair and its definition.

    What is vellus hair?

    Vellus hair, colloquially also known as 'peach fuzz', is fine and short strand growing on the body right from childhood. Vellus strands, lacking melanin, are usually unpigmented, light-colored and nearly transparent.
    Peach fuzz typically refers to the light colored short hair found on the upper lip of young preadolescent boys. Three types of hairs are present in the human body, namely lanugo, vellus and terminal types. The soft strands can be clearly distinguished from terminal type, which is darker, thicker and longer. It can also be distinguished from lanugo type found on fetus. The lanugo is thicker and longer. The fetus sheds lanugo at 30-36 weeks to be replaced by vellus type. In premature babies lanugo may be seen at birth.

    The number of vellus follicles and their distribution in the body are predetermined genetically. Its transformation into terminal type is governed by the gender of the individual, puberty and androgen hormones input. During puberty increase in androgenic hormones cause them to convert into terminal ones in the axillary and pubic areas. During the transition to terminal type, intermediate type of strands can be seen. The soft, light strand's length usually does not exceed 2 mm. due to very short anagen phase.
    Vellus hair

    Vellus follicles, unlike the terminal follicles, do not connect to sebaceous glands. In children, excluding scalp, eyebrows and eyelashes, the body hair is predominantly soft and short. Vellus is very much apparent is children and women. In men they get reduced due to their transformation into terminal ones, whose presence also obscures the presence of those remaining strands. The vellus strands have many functions such as, body insulation, temperature regulation by aiding sweat evaporation and aiding in the perception of touch sensation.
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    Web definition of vellus hair
    Definition by thefreedictionary.com: "Short, fine, usually nonpigmented which covers much of the body."
    Definition by yourdictionary.com: "Short, fine, light-colored, and barely noticeable hair that develops on most of a person's body from his/her childhood."
    Definition by collinsdictionary.com: "short fine unpigmented hair covering the human body."
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    Medical conditions involving vellus hair

    Accelerated vellus syndrome means a condition wherein the anagen phase of the soft, short strands is extended and accelerated. In this accelerated syndrome the slender light colored downy strands gain length. Accelerated syndrome may occur due certain medications as well as abnormal hormonal activity in postmenopausal women and transgender patients.
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    In women with polycystic ovarian syndrome, accelerated syndrome may appear which subsequently convert them into terminal types. This accelerated syndrome is also seen with abundance of vellus as a side effect of diseases like Cushing's syndrome and anorexia nervosa. In male pattern baldness, the bald area is not hairless. The growth of thick, dark terminal strands slow down and the light-colored short vellus strands takeover and cover the bald area.
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    Reference:
    1.Lacarrubba F, Micali G, Tosti A. Absence of vellus in the hairline: a videodermatoscopic feature of frontal fibrosing alopecia. Br J Dermatol. 2013 Aug;169(2):473-4. doi: 10.1111/bjd.12316.
    2.Vogt A, Hadam S, Heiderhoff M, Audring H, Lademann J, Sterry W, Blume-Peytavi U. Morphometry of human terminal and vellus follicles. Exp Dermatol. 2007 Nov;16(11):946-50.


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    Image source: http://en.wikipedia.org/wiki/File:Huid.jpg
    Author: Svdmolen | License: CC BY-SA 3.0
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    Monday, September 22

    Melanocytes definition - What are melanocytes?

    › › › What are melanocytes and their definition.

    What are melanocytes?

    Melanocytes are a type of epidermal cells which produce melanin pigment.
    Melanocytes are present in stratum basale, the deepest layer of the epidermal skin. Up to 10% of the cells present in the basal cell layer are pigment producing cells. These pigment cells are also present in retinal pigment epithelium, stria vascularis of cochlear duct in inner ear, heart, meninges and substantia nigra pars compacta of the midbrain. Three types of melanins are produced and eumelanin and pheomelanin are present in the skin while neuromelanin is found in the brain.

    The number of melanocytes present per square millimeter of skin is between 1000 and 2000. It is not the number of pigment cells present in the skin that contributes to the lighter or darker color of skin. The level of melanin producing activity as well as the types of pigments and their relative amounts contribute to an individual's skin color. The melanin produced by the melanocytes protects the skin from the harmful effects of ultraviolet radiation. The absence of melanin gives rise to skin conditions like albinism and leucism. The total or partial loss of melanin production may cause vitiligo.

    Definition of melanocytes

    Definition by medterms.com: "A cell in the skin that produces and contains the pigment melanin."
    Definition by merriam-webster.com: "an epidermal cell that produces melanin."
    Definition by about.com: "Melanocytes are cells located in the epidermis that are responsible for producing melanin, a brown pigment that helps screen against the harmful effects of UV light."

    Melanoblasts

    The precursor cells of melanocytes arise from the neural crest formed during the gastrulation of the embryo. These neural crest cells migrate to various sites and differentiate to form precursor cells of neurons, endocrine components, bone, cartilage, connective tissue and melanocytes. The precursor pigment cells are known as melanoblasts. The migrating melanoblasts transform into melanocytes and establish at the epidermal-dermal junction to commence melanogenesis. When there is dysregulation in the melanoblast development and migration, skin conditions like piebaldism may occur.

    Melanocyte stem cells

    Melanoblasts also enter the newly forming hair follicles to form hair matrix melanocytes and the stem cells. The stem cells are found as a small pool of immature cells in the lower permanent portion including the bulge region of the hair follicle. Apart from maintaining a supply of pigment cells for hair pigmentation, these stem cells are also a source for melanocyte replacement in the epidermis.
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    Greying of hairs in humans was thought to be due to free radicals causing oxidative stress and cytotoxic damage of the mature melanocytes in the matrix cells. However recent studies indicate that hair graying is due to loss of pigment stem cells. Melanoma occurs when melanocyte development and proliferation pathways are undermined and destabilized.

    Melanocyte structure

    These pigment cells are regularly dispersed among the basal keratinocytes in the basal layer of epidermis at an ratio of about 1:10. They appear larger than the keratinocytes. They have elongated dendrites which are in contact with the neighboring basal and suprabasal keratinocytes. The nucleus is ovoid in shape. These cells contain clear premelanosomes as well as many melanosomes at various maturation stages.

    Melanocyte function

    Many functions of these pigment cells and their product can be listed out. Their main function in many species of animals is camouflage from prey and predators. In humans, protection against UV radiation has evolved as one of the primary functions. Skin pigmentation being the most apparent display of human polymorphic traits, defines ethnicity and race.
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    Heat regulation, redox signaling and antioxidant activity are some of the other functions of melanin. The presence of the melanocytes and melanin is necessary for the proper functioning of inner ear, eyes and midbrain.

    Melanin biosynthesis

    The biosynthesis of melanin by the melanocytes is known as melanogenesis. The melanogenesis normally occurs in a basal level. Under certain conditions, the synthesis may occur in an active manner. In the lighter-skinned people, the basal level of melanogenesis is quite low when compared people with darker skin tone.

    The mechanism of active melanogenesis is triggered by the keratinocytes on exposure to ultraviolet radiation by synthesizing and secreting endothelin-1 (ET-1) an amino acid peptide. The production of the precursor of melanocyte-stimulating hormone (MSH), proopiomelanocortin (POMC) is also stimulated. The rate of mitosis in the basal keratinocytes is also increased. Through a number of biosynthetic cascading pathways, the rate of proliferation of melanocytes and keratinocytes, the melanogenesis activity, and synthesis and transfer of melanosomes is increased.

    Melanocytes and keratinocytes

    As described earlier, melanocytes with the help of their dendrites are in contact with nearly forty basal as well as suprabasal keratinocytes. The pigment cell with its dendrite-connected keratinocytes is termed "the epidermal melanin unit.” These melanin producing cells transfer the melanosomes to the keratinocytes through their multiple dendrites. Once inside the keratinocyte, multiple melanosomes are packed into single membrane pigment globules and transported by motor protein dynein to perinuclear region. Then there is membrane degradation of the pigment cell globules to form a UV-radiation protective cap above the keratinocyte nucleus.

    Melanocytes and hyperpigmentation

    Skin pigmentation is an inherited trait, being regulated by genetic factors on the epidermal cells. However the endocrine secretions, certain medications, chemicals and environmental factors can modulate the distribution of the melanin as well as its amount and type. Endocrine factors induce melanocyte activity and hyperpigmentation occurs temporarily in pregnancy and permanently as age spots. The use of diuretics, levodopa, hydantoins, sulfonamides, tetracyclines, chloroquine and oral contraceptives is associated with hyperpigmentation. Postinflammatory hyperpigmentation of the skin occurs after the resolution of the inflammatory dermatitis, especially in patients with darker skin tone due to enhanced melanocyte activity.
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    Reference:
    1.Osawa M. Melanocyte stem cells. 2009 Jun 30. In: StemBook [Internet]. Cambridge (MA): Harvard Stem Cell Institute; 2008-. Available from: http://www.ncbi.nlm.nih.gov/books/NBK27077/
    2.Audrey Uong, Leonard I. Zon. Melanocytes in Development and Cancer J Cell Physiol. Jan 2010; 222(1): 38–41.
    3.Kvam E, Dahle J. Pigmented melanocytes are protected against ultraviolet-A-induced membrane damage. J Invest Dermatol. 2003 Sep;121(3):564-9.
    4.Iozumi K, Hoganson GE, Pennella R, Everett MA, Fuller BB. Role of tyrosinase as the determinant of pigmentation in cultured human melanocytes. J Invest Dermatol. 1993 Jun;100(6):806-11.

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    Saturday, September 13

    What is hypertrichosis - Hypertrichosis definition

    › › What is hypertrichosis - Definition of hypertrichosis.

    What is hypertrichosis?

    Hypertrichosis is defined as excessive growth of hair. Hypertrichosis disorders may be present at birth, or may be acquired later in life.
    The excessive hair disorders present at birth include congenital syndromes, autosomal mutations and hereditary diseases. The mutation may be spontaneous genetic mutation in autosomal chromosomes or in x-y chromosomes. These excessive hair disorders may also be acquired later in life, triggered by cancers, hormonal anomalies and certain therapeutic drugs. The excess hair growth may be generalized, affecting the whole of the body or localized to form well defined patches.

    Extensive excess growth of hair is also known as Ambras syndrome or werewolf syndrome. These disorders affect both the genders equally. Hypertrichosis is basically different from hirsutism in that it is androgen-independent. Hirsutism is the excessive male-pattern hair growth in women. Hirsutism is an androgen-dependent condition. The excessive growth may be of , or , depending upon the type of syndrome. Generally the palms of the hands, soles of the feet and mucosal surfaces are not affected.

    Web definition of hypertrichosis

    Definition by merriam-webster.com: "excessive growth of hair."
    Definition by reference.md: "Excessive hair growth at inappropriate locations, such as on the extremities, the head, and the back. It is caused by genetic or acquired factors, and is an androgen-independent process."
    Definition by thefreedictionary.com: "An extremely rare (less 100 cases reported worldwide) excess of hair on the body, which can be generalised or localised, congenital or acquired."

    What are the types of hypertrichosis

    Considering the time of appearance, excessive hair growth can be categorized into congenital (present at birth) or acquired (acquired later in life) types. Further these disorders, depending upon the extent, may categorized as generalized or localized types.

    (CH)
    Considering the type of hair (vellus, lanugo or terminal) and extent of excess hair, CH can again be categorized into subtypes.
    CH lanuginosa patient has generalized cover of lanugo hair over the body. It is considered to be an autosomal dominant mutation on chromosome 8q.

    Generalized CH is noticed in men as excessive hair on the face and upper body, whereas women have less severe asymmetrical hair distribution. It is considered to be an autosomal dominant mutation on chromosome x24-q27.1.

    Terminal CH is characterized by whole body being covered by terminal hair. It is considered to be due to a mutation in MAP2K6 on chromosome 17. Further, circumscribed, localized and nevoid forms of CH have been reported.

    Acquired hypertrichosis (AH)
    AH is associated with side effects of medication, presence of cancers and alopecia and glaucoma treatment. AH lanuginosa is characterized by growth of lanugo hair, especially on the face. In some cases it is associated with malignancy. Generalized AH is usually associated with minoxidil treatments. Patterned AH shows hair growth in a pattern formation and is associated with malignancy. Localized AH may appear as well defined excess hair when there is irritation or trauma to the skin.

    What are the causes of hypertrichosis

    Acquired hypertrichosis is caused by the presence of cancer, alopecia medication, hypertension medication, metabolic disorders or hormone imbalances.
    Topical applications like iodine, psoralens, topical minoxidil or topical steroids may also cause acquired hypertrichosis. Congenital hypertrichosis is caused by inherited genetic abnormalities or spontaneous genetic mutations in autosomal or x-y chromosomes.

    What are the options

    There is no treatment for congenital forms of hypertrichosis. Acquired forms resolve when the causative factors are removed or discontinued. Hair removal methods like shaving, waxing, laser hair removal and electrolysis are the treatment options available for congenital hypertrichosis.
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    Reference:
    1.Trüeb RM. Causes and management of hypertrichosis. Am J Clin Dermatol. 2002;3(9):617-27.
    2.Trüeb RM. Hypertrichosis. Hautarzt. 2008 Apr;59(4):325-37; quiz 338.
    3.Goel N, Rajaram S, Gupta B, Gupta K. Familial congenital generalized hypertrichosis. Indian J Dermatol Venereol Leprol 2013;79:849.

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    Sunday, May 25

    What is alopecia areata - Definition of alopecia areata

    › › › Alopecia areata definition
    What is alopecia areata?
    Alopecia areata is the medical term for sudden transient loss of hair in circumscribed patches especially of the scalp or face.
    Initially alopecia areata patches may appear round or oval with the marginal broken hairs having a typical exclamation point or '!' appearance. Though the exact cause is not clear, research evidence suggest an autoimmune origin.

    This disorder is also found to run in families and affects 1.7% of the population at some point in their lives. Alopecia areata is also found to be associated with some autoimmune diseases and hereditary disorders. Intense emotional state of stress, anxiety and panic are common triggering and precipitating factors.

    Both men and women may be affected by this type of alopecia. In men beard area may also be involved. Children and young adults are affected more often than other age groups. Spontaneous remission and recurrence of alopecia areata is common. In some cases the condition may be progressive and result in total hair loss on the head and body.

    Definition of alopecia areata

    National Library of Medicine definition: "Alopecia areata is a condition that causes round patches of hair loss. It can lead to total hair loss."
    Medterms.com definition: "Alopecia areata: Patchy baldness that typically begins with rapid hair loss on discrete areas of the scalp and sometimes progresses to complete baldness and even loss of body hair."
    Merriam-webster.com definition: "sudden loss of hair especially of the scalp or face in circumscribed patches with little or no inflammation."

    What are the types of alopecia areata?

    These patches of hair loss are categorized into subtypes considering the extent of hair loss as well as the affected areas.


  • In some individuals the hairless patches may grow leading to total loss of hair on the scalp in about six months. The condition may become permanent is some individuals whereas in some hair may grow back completely.


    In AA universalis, hair loss may spread to entire epidermis causing total loss of scalp and body hair. The condition may become permanent is some individuals whereas in some hair may grow back completely.

    Alopecia incognita (diffuse alopecia areata)
    AA incognita is a very rare type of hair loss with rapid progress, found mostly in young women. The disorder is clinically different from other types as it is diffuse and is lacking in well-defined patches.

    Alopecia barbae
    Noninflammatory hair loss in sharply defined areas on the chin is known as alopecia barbae. These patches may appear along with patches on the scalp or appear only on the beard area.

    What are alopecia areata causes?

  • In AA with autoimmune origin the body's immune system mistakenly attacks the hair follicles causing hair loss. There is association of the disorder with other autoimmune diseases like autoimmune thyroiditis, diabetes mellitus, vitiligo, rheumatoid arthritis and psoriasis. Some people have the disorder running in their families. In such cases having genetic predisposition certain triggers like severe viral infection, severe stress, panic or anxiety may precipitate hair loss. Certain environmental factors may also play a major role in the etiopathogenesis. Nutritional deficiency, especially iron or zinc deficiency is reported to precipitate the hair loss.

    What are alopecia areata symptoms?

    Sudden loss of hair in round or oval patches is the only symptom. Usually, the hair loss occurs on the scalp. It may also occur on the hairy parts of the body. In very rare cases well-defined linear hair loss is seen. Broken hairs at the edge of the patch may look like exclamation points. In rare instances burning sensation or itching had been reported. Nail pitting, multiple leukonychia and trachyonychia are observed in 30-50% of the cases of alopecia areata.

    Alopecia areata treatment and management

    There is no cure for this disorder. Corticosteroids are the preferred medication in the treatment of this disorder. They may be administered in oral, topical or intralesional preparations.
    Minoxidil, an antihypertensive vasodilator medication, is found to arrest hair loss and stimulate hair growth.
    Anthralin (dithranol) a synthetic oxidative immunosuppressive compound with anti-psoriatic action is used successfully with short contact treatment. It may have side effects like severe irritation and folliculitis.
    Other forms of treatment for alopecia areata include topical immunotherapy, phototherapy, use of prostaglandin analogues, use of topical calcineurin inhibitors, Sulfasalazine use and mesotherapy.
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    References: 1.Deepak SH, Shwetha S. Scalp roller therapy in resistant alopecia areata. J Cutan Aesthet Surg 2014;7:61-2
    2.Seetharam KA. Alopecia areata: An update. Indian J Dermatol Venereol Leprol 2013;79:563-75

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    Wednesday, January 15

    What is melasma? - Definition of melasma

    › › › What is melasma and its definition

    What is melasma?

    Melasma is a hyperpigmentation of the skin, particularly common in women.
    Often pregnant women are affected by melasma and it is also known as chloasma or the mask of pregnancy. Genetic predisposition is one of the triggering factors in the development of melasma.

    This brown discoloration of skin is also found to affect women taking oral contraceptives or undergoing hormone replacement therapy (HRT). Though this cosmetic discoloration is observed both in men and women, only 10% men were observed to develop the lesions.

    Melasma is rarely encountered in teens and young adults. It may appear in thirties and persist for many years. In post menopause women the brown patches may fade completely. It is believed to be linked with estrogen and progesterone hormones which induce hyperactivity of melanocytes on exposure to sun.

    Melasma hyperpigmentation on the face
    picture of melasma on face
    Image by Elord  |  CC BY-SA 3.0
    www.wikidoc.org
    Excess skin pigment synthesis and also increase in the number of melanocytes are the causes of the hyperpigmentation. In pregnant women the lesions may start resolving after giving birth. Similarly the discontinuance of hormonal treatments can help in the resolution of the lesions.

    For prevention and for reducing the lesions avoiding sun exposure and using sunscreens is recommended. In the treatment of the lesions, pigment synthesis blocking agents, skin peels and lasers are being used. There is every possibility of recurrence after the treatment.

    Definition

    by wordnetweb.princeton.edu:
    "a tan discoloration of a woman's face that is associated with pregnancy or with the use of oral contraceptives."

    Medical definition

    by thefreedictionary.com:
    "sharply demarcated, blotchy, brown macules, usually in a symmetrical distribution on the cheeks and forehead and sometimes the upper lip and neck, often associated with pregnancy or other altered hormonal state."

    Encyclopedic definition

    by en.wikipedia.org:
    "Melasma is a tan or dark skin discoloration."




    Picture source: http://www.wikidoc.org/index.php/File:Melasmablemish.jpg
    Picture author: Elord from Wikidocs | License: CC BY-SA 3.0
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    Saturday, January 11

    What is acanthosis nigricans - Definition of acanthosis nigricans

    › › Meaning of acanthosis nigricans and its definition
    What is acanthosis nigricans?
    Acanthosis nigricans (AN) is a skin condition characterized by hyperpigmentation. In this dermatological condition, poorly defined symmetrical hyperkeratosis and verrucous plaques develop giving the affected area of the skin a velvety texture.
    Usually acanthosis nigricans affects the intertriginous areas of skin like the axilla of the arm, the anogenital region, submammary region, groins and sides of the neck.
    In very rare cases the condition may be generalized as seen in the image. Occasionally mucocutaneous areas may get affected.

    'Acanthosis' is diffused thickening (hyperplasia) of epidermal skin.
    There is increased thickness of stratum basale and stratum spinosum. It is derived from the Greek word "Acanthus" meaning "thorn".
    In the advanced condition, verrucous plaques giving spiny appearance may develop.
    The word "nigricans", is from the Latin, meaning "becoming black".
    Acrochorda (fibroepithelial polyps), small benign tumors, are usually associated with AN. There are benign and malignant forms of acanthosis nigricans. The causes of this disorder include, obesity, endocrine abnormalities and genetic inheritance. Malignant forms may involve mucous membranes and are usually associated with gastrointestinal and genitourinary cancers. Treating the causative factors gradually resolves the condition in most of the cases.
    picture of acanthosis nigricans affected back

    Acanthosis nigricans definition

    by wordnetweb.princeton.edu/:
    "a skin disease characterized by dark wartlike patches in the body folds; can be benign or malignant."
    Medical definition
    by www.merriam-webster.com:
    "a skin disease characterized by gray-black warty patches usually situated in the axilla or groin or on elbows or knees and sometimes associated with cancer of abdominal viscera."
    Encyclopedic definition
    by en.wikipedia.org:
    "Acanthosis nigricans is a brown to black, poorly defined, velvety hyperpigmentation of the skin."



    Authors: Vandana Mehta Rai MD DNB, C Balachandran MD | License: CC BY-SA 3.0
    Current topic in the dynamic natural skin care:
    What is acanthosis nigricans and its definition.

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    Thursday, August 12

    Skin care - What causes dry skin

    Causes of dry skin → What is dry skin? → Moisturizers → Homemade face moisturizer recipe → Oily epidermis treatments
    Dry skin causes can be either external or internal, which have to be addressed specifically for relief. There are many factors and causes inducing dry skin condition and some of them are dietary deficiencies, weather elements and sun exposure, frequent baths and harsh soaps, hormonal deficiencies, genetic factors and skin diseases.
    The causes of dry skin can be corrected easily by removing the affecting factors.
    However the internal factors, especially diseases, take long term medical management.

    Dry skin causes: dietary deficiencies

    This condition can result very easily when there is insufficient intake of water or dehydration of body cells.
    The deficiencies of B-complex vitamins and vitamin A have been found to be causes of dry skin.
    Riboflavin deficiency leads to cracks in the corner of the mouth.
    Higher amounts of alcohol, caffeine and fried food are likely causes of dry skin.
    Irregular food habits and smoking lead to chronic xeroderma.

    Dry skin causes: weather and sun exposure

    Winter leads to xeroderma condition as the epidermis loses water due to lowest humidity levels prevailing in winter.
    There is a mistaken notion that winter with its cold conditions is rich in moisture; but the reverse is true.
    Winter winds are dry and whatever moisture in it is already deposited as snow.
    A good example is the refrigerator, wherein if a plump tomato is left in circulating air, it appears shriveled after some time due to loss of water.
    Similarly hot air can also be devastating for the epidermis, robbing it of its moisture as it happens in desert regions.
    Pollutants, smoke, dust and high levels of ozone can be causes of dry skin condition.
    Lack of balanced diet along with malnutrition results in xeroderma.
    Direct sunlight by its heating effect dehydrates the epidermis.
    Longer exposure also damages the inner dermis cells affecting their functions in moisturizing the epidermis.
    The deeper collagen and elastin tissues are also damaged due to long exposures to sunlight; this causes wrinkles and increase in surface area for evaporation.
    Sunstroke and heatstroke leads to xeroderma.

    Dry skin causes: low humidity induced by air-conditioning and heating

    When there is low humidity (low concentration of moisture in air) epidermis may easily lose its moisture, especially when the protective mantle is damaged or disturbed.
    Apart from winter, reasons of low humidity can be due to air-conditioning, central heating, fireplaces, space heaters and furnaces.
    In these situations the conditions can be greatly improved by installation of humidifiers.

    Dry skin causes: frequent baths and chemicals in water

    Bath tends to remove the protective mantle of the epidermis.
    However to keep our skin from excess of sebum, dead cells and bacteria bath is required.
    Too frequent baths or showers remove much of the protecting sebum layers resulting in xerosis conditions.
    Hot baths and bathing for long time also damages the lipid barriers.
    Heavily chlorinated bath water or swimming pool can also damage the protective layer leading to xerosis.

    Dry skin causes: detergents, harsh soaps, shampoos, wrong moisturizers and makeup

    Most of the bath soaps and detergents are alkaline in nature.
    The protective lipid layer of the epidermis is acidic in nature and it gets neutralised and damaged by the harsh alkaline soaps.
    Most of the anti-bacterial preparations, deodorants and shampoos are made to give the proclaimed results, but are devastating for the protective lipid layer.
    Use of unsuitable cleansers, toners, moisturizers and make-up are major reasons for xeroderma.
    Cosmetics made for oily skin conditions when applied on normal epidermis may take away extra moisture and oil causing xerosis.
    Many of the chemical ingredients in cosmetics can be the causes of xeroderma.
    Mineral oils and pH balancers damage acid mantle protecting the epidermis.

    Dry skin causes: aging process

    With old age the collagen and elastin tissues become thinner; adding to this condition is the decreased out put of sebum due declining androgen secretion.
    The loss of sebum layer leads to xerosis conditions in the aged.

    Dry skin causes: hypothyroidism and hormonal imbalance

    Thyroid disorder like hypothyroidism causes decrease in the production of thyroid hormones.
    The activity of the sebaceous glands and sweat glands is reduced in the absence of thyroid hormones and causes scaly skin.
    Hormonal imbalance also causes dry skin.
    Many women experience oily or dry skin conditions at some stage of their pregnancy due to changing hormonal profile.
    Persons with affected androgen production experience lowered sebum production and xerosis.
    Hormonal imbalances of progesterone and estrogen during menopause drastically reduces the sebum production.

    Dry skin causes: genetic factors, diseases and skin ailments

    Many people are genetically prone to xerosis.
    Due to certain genetic diseases androgen production is reduced resulting in xerosis.
    Ichthyoses are mostly genetic skin disorders. All these disorders are characterised by thickened, flaky or scaly epidermis.
    The most common among them is ichthyosis vulgaris accounting for nearly 95% of cases.
    In such genetic disorders even infants can have severe dry skin.
    Diseases, especially skin diseases, lead to xerosis. Kidney ailments, diabetes, auto-immune diseases, sarcoidosis, chemical poisoning, rubbing of chemicals like alcohol and kerosene, Anorexia Nervosa, HIV/AIDS, Sjogren's syndrome, Hodgkins' disease, cancer, chronic diarrhea, pituitary deficiency, allergies, seborrhea, eczema, lichen infection, dermatitis, fungal skin infections and psoriasis are major medical causes of xerosis.
    Sebaceous glands
    Certain antihistamines, antispasmodics, retinoids, cholesterol lowering drugs (niacin) and diuretics can lead to dry skin.

    Lack of exercise, lack of sleep and poor blood circulation are some of the causes of dry skin.

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